A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
نویسندگان
چکیده
An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.
منابع مشابه
Pharmacological properties of some 3-substituted indole derivatives, a concise overview
Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2017